Program

PROGRAM

Day 1

Welcome: 09:55am

  

Session 1: 10:00-11:30am:

  

Session title: Central cardiovascular control in health and disease

Chair: Emilio Badoer

10:00-10:15 1.1 Clonidine restores vascular reactivity to vasopressors during hyperdynamic sepsis in conscious sheep - Yugeesh, Lankadeva (Florey Institute)

10:15-10:30 1.2 Reducing cardiac filling pressures decreases cardiac cardiac norepinephrine spillover but not cardiac sympathetic nerve activity in heart failure - Rohit Ramchandra (Florey Institute) 

10:30-10:45 1.3 Role of the area postrema in heart failure - Yonis Abukar (Florey Institute) 

10:45-11:00 1.4 Sympathetic baroreflex sensitivity: is there an effect of time of day? - Chloe Taylor (University of Western Sydney) 

11:00-11:15 1.5 Can post-stroke upper-limb rehabilitation increase cardiovascular fitness? - Penelope McNulty (Neuroscience Research Australia, Sydney) 

  

Morning Tea 11:15-11:35am

Session 2: 11:35-12:50 pm 

Session title: Neuroendocrine cardiovascular control

Chair: Pamela Davern

11:35-12:50 2.1 Proteomic changes in the RVLM of SHR compared to WKY - Ann Goodchild (Macquarie University, Sydney)

11:50-12:05 2.2 Neurochemical code of ventrolateral medulla neurons that regulate homeostatic blood pressure or blood glucose responses - Lindsay Parker (Macquarie University, Sydney) 

12:05-12:20 2.3 Cardio-respiratory responses to bicuculline microinjections in the hypothalamus after single or dual orexin receptor blockade in the anesthetized rat - Irfan Beig (University of New South Wales) 

12:20-12:35 2.4 Orexin’s contribution to high blood pressure in the spontaneously hypertensive rat - Pascal Carrive (University of New South Wales) 

12:35-12:50 2.5 Contribution of orexin to neurogenic hypertension in BPH/2J mice - Kristy Jackson (Baker IDI Heart and Diabetes Institute) 

  

Lunch and posters 12:50-2:05pm

1. Dietary salt enhances inflammation in the cardiovascular centres of diabetic rats - Alahmadi Emad - School of Medical Sciences and Health Innovations Research Institute, (RMIT University, Melbourne)

2. Central autonomic and cardiovascular dysfunction in seizure and sudden unexpected death in epilepsy - Amol Bhandare (Australian School of Advanced Medicine, Macquarie University, Sydney)

3. Regulation of sympathetic nerve activity by adipokines - Hamza Habeeballah (School of Medical Sciences and Health Innovations Research Institute, RMIT University, Melbourne).

4. Role of microglia in cardiovascular neurons: a morphological analysis - Komal Kapoor (Australian School of Advanced Medicine, Macquarie University, Sydney).

5. Altered cardiovascular and sympathetic activity in response to psychological stress in the dexamethasone programmed rat - Louise Prestipino (School of Medical Sciences and Bosch Institute, The University of Sydney)

  

Session 3: 2:05-3:05pm

Session title: CNS contribution to stress and thermoregulation 

Chair: Pascal Carrive

2:05-2:20 3.1 Positive allosteric modulation of GABAA receptors on stress and hypertension in Schlager hypertensive mice - Pamela Davern (Baker IDI Heart and Diabetes Institute)

2:20-2:35 3.2 Understanding the link between emotional stress, angiotensin II and the amygdala - Alya Dwiana (The University of Melbourne) 

2:35-2:50 3.3 Mechanisms that contribute to the methamphetamine induced increase in brown adipose tissue temperature - Sarah Hassan (Macquarie University Sydney) 

2:50-3:05 3.4 The direct cooling of the preoptic-hypothalamic area elicits the release of thyroid stimulating hormone during wakefulness but not during rem sleep - Davide Martelli (Florey Institute) 

  

Afternoon Tea 3:05-3:25pm

Session 4: 3:25-5:00 pm

Session title: Central control of the kidney 

Chair: Clive May

3:25-3:40 4.1 Intrarenal nerves in diabetes and hypertension: - Anna Watson (Baker IDI Heart and Diabetes Institute)

3:40-3:55 4.2 Effects of renal denervation in genetically hypertensive mice - Cindy Gueguen (Baker IDI Heart and Diabetes Institute)

3:55-4:10 4.3 Reinnervation of renal afferent and efferent nerves at 5 ½ and 11 months after catheter-based radio-frequency renal denervation in sheep - Lindsea Booth (Florey Institute) 

4:10-4:25 4.4 Functional regrowth of the nerves to the renal vasculature following denervation - Kate Denton (Monash University) 

4:25-4:40 4.5 Role of angiotensin II in baroreflex and peripheral  chemoreflex control of sympathetic nerve activity in chronic kidney disease - Yimin Yao (Macquarie University, Sydney) 

4:40-4:55 4.6 Role of the renal nerves in a conscious rabbit model of chronic kidney disease - Geoffrey Head (Baker IDI Heart and Diabetes Institute)

4:55 DSI Presentation by Professor Geoffrey Head

5:00 ISAN AGM

  

Dinner 6:00-late: Village Melbourne  

11 minute walk from Baker Institute

  

  

PROGRAM

Day 2

Session 5: 9-10:30am:

  

Session title: Role of the CNS in obesity induced hypertension 

Chair: Geoffrey Head

9:00-9:15 5.1 Augmented endothelial-specific-arginine transport blunts the contribution of the sympathetic nervous system to obesity induced hypertension in mice – Niwanthi Rajapakse (Baker IDI Heart and Diabetes Institute)

9:15-9:30 5.2 Resistin A Cytokine From Fat Tissue – Emilio Badoer (RMIT University, Melbourne) 

9:30-9:45 5.3 Should we target sympathetic nervous system activity in the management of obesity? – Elizabeth Lambert (Baker IDI Heart and Diabetes Institute) 

9:45-10:00 5.4 Developmental origin of obesity related hypertension: trans-generational cardiovascular impact of high fat diet feeding in rabbits – Joon Lim (Baker IDI Heart and Diabetes Institute)

10:00-10:15 5.5 Altered gut-brain signalling and obesity related hypertension – Daniela Sartor (University of Melbourne)

10:15-10:30 1.6 The effect of gestational high fat diet on cardiovascular responses to dehydration and air jet stress – Hasthi Dissanayake (University of Sydney) 

Morning Tea 10:30-10:45am

Session 6: 10:45-12:15pm 

Session title: Central Control of Respiration

Chair: Mathias Dutschmann

10:45-11:00 6.1 Functional and structural changes in the brain associated with the increase in muscle sympathetic nerve activity in obstructive sleep apnoea - Vaughan Macefield (University of Western Sydney)

11:00-11:15 6.2 Spontaneous swallowing occurs during autoresuscitation in the in situ preparation of rodent – Tara Bautista (Florey Institute) 

11:15-11:30 6.3 Investigating the origins of cardiac vagal tone – David Farmer (Florey Institute)

11:30-11:45 6.4 Efferent projections from the inferior colliculus to putative cardiorespiratory control neurons – Bowen Dempsey (Macquarie University) 

11:45-12:00 6.5 Somatostatin type 2a receptors (sst2a) are not expressed on respiratory neurons in the ventral respiratory column (VRC) – Sheng Le (Macquarie University)

12:00-12:15 6.6 Elucidating the role of the nucleus retroambiguus in the generation of respiratory rhythm - Sarah Jones (The Florey Institute of Neuroscience and Mental Health) 

Lunch 12:15-1:00PM

Session 7: 1:00-2:15 PM

Session title: Role of the NTS

Chair: Ann Goodchild

1:00-1:15 7.1 Role of neuronal AT1AR in the NTS on baroreflex mediated heart rate changes - Yan-Ting Choong (The University of Melbourne)

1:15-1:30 7.2 Functional integration of neurons arising by adult neurogenesis in the nucleus of the solitary tract – Amber Darwinkel (The University of Melbourne) 

1:30-1:45 7.3 Differential modulation of solitary tract excitability by angiotensin II type 1A receptor in the nucleus of the solitary tract in mice – David Carter (The University of Melbourne) 

1:45-2:00 7.4 Polysialic acid in the nucleus of the solitary tract alters neuronal excitability to modify blood pressure and the baroreflex – Phil Bokiniec (Macquarie University) 

2:00-2:15 7.5 Synaptic gating by interneuron input at second order NTS neurons– Stuart McDougall (The University of Melbourne) 

  

Afternoon Tea 2:15-2:35PM

  

Session 8: 2:20-3:30

Session title: Emerging topics/technical innervations  

Chair: Vaughan Macefield

2:35-2:50 8.1 Impact of in vitro embryo culture and transfer on blood pressure regulation and cardiac hypertrophy in fetal and postnatal life - Monalisa Padhee (University of South Australia)

2:50-3:05 8.2 Cardiac sympathetic nerve activity and its segmental origins in the rat – Natasha Pracejus (The University of Melbourne)

3:05-3:20 8.3 Development of cell-type specific promoters for elucidating neural circuits – David Hawkes (Florey Institute)

3:20-3:35 8.4 Controlling neuronal activity – Andrew Allen (The University of Melbourne)

3:35-3:55 8.5 Rapid production of transgenic animals using CRISPR/cas9 - Marco Herold (WEHI)

3:55 Closing comments and discussion: David Hawkes

4:15 Drinks and farewells 

  

  

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